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Clinical Research
About Clinical Research
The Foundation for Orthopaedic Research and Education (FORE) has a commitment to excellence in clinical research. Since the Foundation's inception in 1999, the clinical research department has rapidly expanded and now conducts orthopaedic clinical trials in such sub-specialties as foot, ankle, knee, hip, spine, elbow, shoulder, and sports medicine. FORE is dedicated to performing high-quality, ethically sound, scientifically meritorious clinical research that will advance orthopaedic treatment and patient care.
FORE conducts an array of research studies, including:
- IDE (investigational device exemption) studies
- ND (investigational new drug) studies
- Randomized, controlled trials
- Industry sponsored studies
- Investigator-initiated studies (prospective and retrospective)
- Case studies
Current Studies
Elbow Research
- Multi-Center Prospective Elbow Study
Hand Research
- Total Wrist Arthroplasty
- Dupuytren's
- Hand Infection Study
- Tendon Rupture in Relation to Distal Radius Fracture
- Buddy Tape vs. Casting Randomized Clinical Study
- Wrist Fusion for SNAC/SLAC
- PRC OATS Technique Article
- Collagenase for Post-Traumatic Scar Contracture
- Retrograde IM MC Screw
Hip and Knee Research
- Resurfacing Hip System
- Outpatient Management following Total Joint Arthroplasty
- 10-Year Knee System Follow-up
- Revision Total Knee Arthroplasty
- Post-operative TKA blood loss comparison
- Tibial defects in revision TKA
- Gender-specific vs Traditional TKA comparison
- Acetabular Bone Deficiency
Shoulder Research
- Failed Total Shoulder Arthroplasty
- Strength and Shoulder Arthroplasty
- Midshaft Humerus Nonunions
- Proximal Humerus Malunions
- Shoulder Chondrolysis and Shoulder Arthroplasty
- Clinical Outcomes of Reverse Shoulder Prosthesis
- Characteristics of Reverse Shoulder Prosthesis patients
- Glenohumeral and Scapular Motion in Shoulder Arthroplasty patients
Spine Research
- Vertebral Body Compression Fractures
- Degenerative Lumbar Spinal Stenosis
- Treatment of Degenerative Disc Disease
- Prospective Multi-center safety and efficacy study
- Restoration of Vertebral Body Anatomy in Kyphoplasty
- Treatment of Single-Level Degenerative Spinal Disc Disease
- Management of Chronic Pain
- Degenerative Spinal Stenosis Following Neural Decompression and Facetectomy
- Fusion Assessment
- Treatment of Symptomatic Cervical Disc Disease
- Treatment Comparison for Patients Receiving Decompression Surgery
- Decompression Surgery for Lumbar Spinal Stenosis
- Radiographic Evaluation
- Posterior Spinal Fusion
Sports Research
- Screw Resorption After ACL Reconstruction
- Safety and Efficacy of Cartilage Implant
- Musculoskeletal Tumors
Clinical Publications 2006-2010
Elbow
Mighell, M., Virani, N., Echols, E., Shannon, R., Badman, B., Keating, C. Large Coronal Shear Fractures of the Capitellum and Trochlea Treated with Headless Compression Screws. J Shoulder Elbow Surg, 2009 Aug 5. [Epub ahead of print]
Mighell MA, Harkins D, Klein D, Schneider S, Frankle M. Technique for internal fixation of capitellum and lateraltrochlea fractures. J Orthop Trauma. 2006 Nov-Dec;20(10):699-704.
Foot & Ankle
Herscovici D Jr, Scaduto JM, Infante A. Conservative treatment of isolated fractures of the medial malleolus. J Bone Joint Surg Br. 2007 Jan;89(1):89-93.
Tarkin IS, Mormino MA, Clare MP, Haider H, Walling AK, Sanders RW. Anterior plate supplementation increases ankle arthrodesis construct rigidity. Foot Ankle Int. 2007 Feb;28(2):219-23.
Hip
Bernasek TL, Lee WS, Lee HJ, Lee JS, Kim KH, Yang JJ. Minimally invasive primary THA: anterolateral intermuscular approach versus lateral transmuscular approach. Arch Orthop Trauma Surg. 2010 Jan 13.
Bernsek TL, Stahl JL, Pupello D. Pyrolytic carbon endoprosthetic replacement for osteonecrosis and femoral fracture of the hip: a pilot study. Clin Orthop Relat Res. 2009 Jul; 467(7):1826-32.
Gustke, K. Surgical nuances to minimize muscle damage during the direct lateral approach in minimally invasive hip replacement. Instr Course Lect. 2008;57:235-41.
Trousdale RT, Callaghan JJ, Gustke KA, A Krackow K, Ritter MA, Schmalzried TP. What would you do? Challenges in hip surgery. J Arthroplasty. 2007 Jun;22(4 Suppl 1):116-22.
Bernasek TL, Haidukewych GJ, Gustke KA, Hill O, Levering M. Total hip arthroplasty requiring subtrochanteric osteotomy for developmental hip dysplasia: 5- to 14-year results. J Arthroplasty. 2007 Sep;22(6 Suppl 2):145-50. Epub 2007 Jul 27.
Durkin A, Sagi HC, Durham R, Flint L. Contemporary management of pelvic fractures. Am J Surg. 2006 Aug;192(2):211-23. Review.
Sanchez-Sotelo J, Haidukewych GJ, Boberg CJ. Hospital cost of dislocation after primary total hip arthroplasty. J Bone Joint Surg Am. 2006.
Haidukewych GJ, Jacofsky DJ, Hanssen AD, Lewallen DG. Intraoperative fractures of the acetabulum during primary total hip arthroplasty. J Bone Joint Surg Am. 2006 Sep;88(9):1952-6.
Knee
Gustke KA. The Natural-Knee system: 25 years of successful results. Am J Orthop (Belle Mead NJ). 2010 Jun;39(6 Suppl):5-8.
Lyons, Steven. One-Stage Bilateral Total Knee Arthroplasty versus Staging Them. In Della Valle, Bach (ed). Curbside Consultation in Knee Arthroplasty. Thorofare, New Jersey. SLACK Incorporated. 2008. Chapter 6.
Mabry TM, Jacofsky DJ, Haidukewych GJ, Hanssen AD. Comparison of Intramedullary Nailing and External Fixation Knee Arthrodesis for the Infected Knee Replacement. Clin Orthop Relat Res. 2007 Apr 26.
Haidukewych G, Sems SA, Huebner D, Horwitz D, Levy B. Results of polyaxial locked-plate fixation of periarticular fractures of the knee. J Bone Joint Surg Am. 2007 Mar;89(3):614-20.
Shoulder
Holcomb JO, Frankle M. Counterpoint: should rotator cuff tears be repaired early? Orthopedics 2010;33:230-1.
Holcomb JO, Hebert DJ, Mighell MA, Dunning PE, Pupello DR, Pliner MD, Frankle MA. Reverse shoulder arthroplasty in patients with rheumatoid arthritis. J Shoulder Elbow Surg. 2010 Apr 1. [Epub ahead of print]
Klein SM, Badman BL, Keating CJ, Devinney DS, Frankle MA, Mighell MA. Results of surgical treatment for unstable distal clavicular fractures. J Shoulder Elbow Surg. 2010 Mar 23. [Epub ahead of print]
Klein SM, Dunning P, Mulieri P, Pupello D, Downes K, Frankle MA. Effects of acquired glenoid bone defects on surgical technique and clinical outcomes in reverse shoulder arthroplasty. J Bone Joint Surg Am 2010;92:1144-54.
Mulieri PJ, Holcomb JO, Dunning P, Pliner M, Kent Bogle R, Pupello D, Frankle MA. Is a formal physical therapy program necessary after total shoulder arthroplasty for osteoarthritis? J Shoulder Elbow Surg. 2009 Sep 30. [Epub ahead of print]
Holcomb J O, Cuff D, Petersen S A, Pupello D R, Frankle M A. Revision reverse shoulder arthroplasty for glenoid baseplate failure after primary reverse shoulder arthroplasty. J Shoulder Elbow Surg.2009 Sept-Oct;18(5):717-23.
Klein SM, Levy JC, Holcomb JO, Pupello D, Frankle M. Treatment of Advanced Rotator Cuff Dysfunction with Reverse Shoulder Arthroplasty. Minerva Orthop Traumatol, 2009; 60:29-46.
Chacon A, Virani N, Shannon R, Levy JC, Pupello D, Frankle M. Prospective evaluation of Reverse Shoulder Prosthesis-allograft composite for the revision of failed arthroplasty associated with proximal humeral bone deficiency. Journal of Bone and Joint Surgery (Am) 2009.
Badman, B., Mighell, M. Proximal Humerus Nonunions Treated with Fixed-Angle Locked Plate and Intramedullary Strut Allograft. J Orthop Trauma, March 2009; 23(3):173-179.
Frankle, Mark. Rotator Cuff Deficiency of the Shoulder. New York: Thieme, 2008.
Cuff D, Pupello D, Virani N, Levy J, Frankle M. Reverse shoulder arthroplasty for the treatment of rotator cuff deficiency. J Bone Joint Surg Am. 2008 Jun;90(6):1244-51.
Virani NA, Harman M, Li K, Levy J, Pupello DR, Frankle MA. In vitro and finite element analysis of glenoid bone/baseplate interaction in the reverse shoulder design. J Shoulder Elbow Surg. 2008 May-Jun;17(3):509-21. Epub 2008 Mar 7.
Levy JC, Virani NA, Frankle MA, Cuff D, Pupello DR, Hamelin JA. Young patients with shoulder chondrolysis following arthroscopic shoulder surgery treated with total shoulder arthroplasty. J Shoulder Elbow Surg. 2008 May-Jun;17(3):380-8. Epub 2008 Mar 7.
Cuff DJ, Virani NA, Levy J, Frankle MA, Derasari A, Hines B, Pupello DR, Cancio M, Mighell M. The treatment of deep shoulder infection and glenohumeral instability with debridement, reverse shoulder arthroplasty and postoperative antibiotics. J Bone Joint Surg Br. 2008 Mar;90(3):336-42.
Rose PS, Adams CR, Torchia ME, Jacofsky DJ, Haidukewych GG, Steinmann SP. Locking plate fixation for proximal humeral fractures: initial results with a new implant. J Shoulder Elbow Surg. 2007 Mar-Apr;16(2):202-7.
Levy JC, Virani N, Pupello D, Frankle M. Use of the reverse shoulder prosthesis for the treatment of failed hemiarthroplasty in patients with glenohumeral arthritis and rotator cuff deficiency. J Bone Joint Surg Br. 2007 Feb;89(2):189-95. Review.
Levy J, Frankle M, Mighell M, Pupello D. The use of the reverse shoulder prosthesis for the treatment of failed hemiarthroplasty for proximal humeral fracture. J Bone Joint Surg Am. 2007 Feb;89(2):292-300.
Frankle M, Levy JC, Pupello D, Siegal S, Saleem A, Mighell M, Vasey M. The Reverse Shoulder Prosthesis for Glenohumeral Arthritis Associated with Severe Rotator Cuff Deficiency. A Minimum Two-Year Follow-up Study of Sixty Patients Surgical Technique. J Bone Joint Surg Am. 2006 Sep;88 Suppl 1 Pt.
Spine
Sagi HC. Technical aspects and recommended treatment algorithms in triangular osteosynthesis and spinopelvic fixation for vertical shear transforaminal sacral fractures. J Orthop Trauma. 2009 May-Jun;23(5):354-60.
Mahiquez M, Bunton KL, Carney G, Weinstein MA, Small JM. Nonsurgical treatment of lumbosacral blastomycosis involving L2-S1: a case report. Spine. 2008 Jun 1;33(13):E442-6.
Castellvi AE, Andrew SA. Scient'x IsoBar TTL Dynamic Rod Stabilization. In: Motion Preservation Surgery of the Spine: Advanced Techniques and Controversies. Elsevier Health Sciences. 2008.
All Upcoming CME
- 2012 Atlanta Trauma Symposium: Cutting-Edge for the Community Fracture Surgeon
- 2012 Fellows Day
- 2012 Orthopaedics for the Primary Care Practitioner & Rehabilitation Therapist
- 2012 Current Solutions in Orthopaedic Trauma
- 2013 Current Solutions in Shoulder and Elbow Surgery
- 2013 Selby Spine
- 2013 Current Solutions in Spine Surgery
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